Date/Time
Date(s) - Tue 18 March
12:00 - 13:00
Location
Seminar Room, Malaghan Institute, VUW
Please join Dr Ian Myles Seminar for the Malaghan Visiting Speaker Programme
Bio: Dr. Myles, attended college at Colorado State University, medical school at the University of Colorado, internal medicine residency at The Ohio State University, and then performed his fellowship training in allergy and clinical immunology at NIH. He began his research career investigating S. aureus skin infections. But since transitioned to become the head of the Epithelial Therapeutics Unit to evaluate the efficacy and safety of a topical, live bacterial treatment for atopic dermatitis (eczema) as well as the chemical agents that may be causing the modern rise in allergic disease.
Eczema Comes From Air Pollution: How chemical exposure is causing the modern atopy pandemic
Although atopic dermatitis has always been viewed as multifactorial, early research was dominated by overlapping genetic determinist views of either innate barrier defects leading to inflammation or innate inflammation eroding skin barrier function. Since 1970, however, the incidence of AD in the United States has increased at a pace that far exceeds genetic drift, thus suggesting a modern, environmental etiology. Similarly, the recently implicated dysbiosis would require induction by an environmental factor. This talk will review the evidence supporting the environmental hypothesis of AD etiology and detail the molecular mechanisms of each of the AD-relevant toxins. Dr Myles will also outline how a pollution-focused paradigm demands earnest engagement with environmental injustice if the field is to meaningfully address racial and geographic disparities. Identifying specific toxins and their mechanisms can also inform in-home and national mitigation strategies.
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Meeting ID: 434 024 110 759
Passcode: Kb6Hv7jq